0474. Circulating mitochondrial dna and vitamin d in critical illness
نویسندگان
چکیده
Methods We performed a prospective observational cohort of MICU patients at the Brigham and Women’s Hospital from 2008-2010 [n=49]. The exposure of interest was 25(OH)D categorized a priori as deficiency (25(OH)D ≤ 15 ng/mL) and measured via competitive chemiluminescence immunoassay. Circulating plasma mitochondrial DNA (mt-DNA) were assessed by measuring copy number of the NADH dehydrogenase 1 gene using quantitative real-time PCR. Plasma 25(OH)D was measured from the same plasma sample as mtDNA. Adjusted associations were estimated through fitting of multivariable logistic regression models including covariate terms for potential confounders of interest. Time-to-event analysis was performed using Cox proportional hazard regression.
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